Testosterone
Testosterone gel (AndroGel T gel 1% CIII) containing 1% T (10 mg/g). About 9–14% of the steroid in the gel applied is available to the body. Thus 10 g of gel applied to the skin contains 100 mg T and delivers approximately 10 mg T to the body per day. Avoid showering until 5 h after application.
Delivers testosterone after appl. for approximately 24 hours "It is the first study to demonstrate that long-term use of testosterone gel replacement is both safe and effective" .Each 5- to 10-g tube or packet of 1% gel contains 50�100 mg of T. Each gel is formulated with a skin-penetration enhancer and is ≥67.0% ethanol by volume. After daily (preferably morning) application of each agent to clean, dry, intact skin of the upper arms or shoulders (and/or abdomen), 10% of each dose (5�10 mg) is absorbed into the systemic circulation over a 24-h period.
Pharmacokinetics. In a pharmacokinetics study involving hypogonadal men receiving two 2.5 mg T patches, ~4�5 mg was absorbed daily from patches applied to the back, thigh, upper arm, or abdomen compared with 3�4 mg for the chest or shin.
Hypogonadal men 8 nmol/L afther 6 months
with per day:
5 gram 1% rise to 17 nmol/L.
7.5 gram 1% 22 nmol/L
10 gram 1% 26 nmol/L.
{T total serum 9.6 ref 8.0 - 35 nmol/L 5g 18 nmol - 10g
27 nmol}
Free Testosterone Hypogonadal men 0.15 nmol/L afther 6 months
with per day:
5 gram 1% 0.30 nmol/L
7.5 gram 1% 0.40 nmol/L
10 gram 1% 0.43 nmol/L
{T free serum 0.25 ref 0.24 - 1.04 5g 0.40 nmol -
10g 0.53 nmol}
Maar in de cel gemeten te laag.
Normale bloedwaarden voor carnitine zegt niets over de intracellulaire waarde van carnitine.
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Biologisch Medisch Centrum Utrecht Epe Paul van Meerendonk
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Behandeling CVS/ME
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Dr Myhill
Dr Teitelbaum
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Dr
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esme
Glutathion
Vitamine
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Nac
D-ribose
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